A Presanitized Pujrpose-Designed Single-Use TFF Strategy

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Downstream Case Study

A Presanitized, Purpose-Designed, Single-Use TFF Strategy

Hélène Chochois, Jean Blehaut, Michael Labreck

BioProcess International, June 2009

As downstream processing accounts for about 70% of the total biomanufacturing cost, it is easy to see why improvements in product recovery and purification are urgently needed. One possible response to this need is the implementation of a single-use TFF process strategy.

Sius “single-use” cassettes provide a unique solution for a cost-effective downstream processing, with measurable cost-in-use savings, while eliminating a significant amount of time performing burdensome clean-in-place (CIP) procedures. This case study outlines the experimental design, development studies, and proposed single-use commercial TFF process based on work performed by Mike LaBreck at Groupe NovaSep.

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